Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.

نویسندگان

  • Véronique Dubois
  • Laurent Poirel
  • François Demarthe
  • Corinne Arpin
  • Laure Coulange
  • Luciene A R Minarini
  • Marie-Christine Bezian
  • Patrice Nordmann
  • Claudine Quentin
چکیده

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

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منابع مشابه

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 10  شماره 

صفحات  -

تاریخ انتشار 2008